TAB2

Name

TGF-beta activated kinase 1 (MAP3K7) binding protein 2

Type

protein-coding

Position

149,218,641–149,411,901 (+)

Aliases

CHTD2, MAP3K7IP2, TAB-2

Ensembl

ENSG00000055208

RefSeq RNA

NM_001292034.3, NM_001292035.3, NM_001369506.1, NM_015093.6, NM_145342.1

RefSeq protein

NP_001278963.1, NP_001278964.1, NP_001356435.1, NP_055908.1, XP_011533935.1

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].

via MyGene.info

Gene · Ensembl

TGF-beta activated kinase 1 (MAP3K7) binding protein 2

Symbol

TAB2

Biotype

Protein coding

Organism

Homo sapiens

Location

6:149,218,641-149,411,901

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein MAP3K7IP2 PDB 2dae.png

via Wikidata · CC0