tumor necrosis factor

Also known as TNF, macrophage-derived, tumor necrosis factor ligand 1F, tumor necrosis factor ligand superfamily member 2, TNF, TNF, monocyte-derived, cachectin, APC1 protein, TNF-a

Human protein

OverviewAI-generated

Tumor necrosis factor is a human protein encoded by the TNF gene. The protein consists of 233 amino acids and has a mass of 25,644. It is classified as a cytokine and is associated with the cell membrane. Structural features include a disulfide bond, and its three-dimensional structure has been determined. Evidence for the protein’s existence is established at the protein level.

The subject is referenced by 1,295 other encyclopedia articles. Additionally, 489 clinical trials have been identified in connection with tumor necrosis factor.

Synthesized by Vinony from 13 facts across 4 sources: Wikidata, ClinicalTrials.gov, UniProt, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

In the Vinony graph

Vinony's link graph records 1,295 inbound references to tumor necrosis factor, and connects out to interleukin-1 family, Alzheimer's disease and white blood cell.

It is catalogued under topics including Cytokines, Genes on human chromosome 6 and Immunostimulants.

Vinony links it to 35 Wikipedia language editions.

Key facts

Pdb: Ortholog search: PDBe RCSB

via Wikipedia infobox

Protein · UniProt

Tumor necrosis factor

Gene: TNF
Organism: Homo sapiens (Human)
Length: 233 aa
Molecular mass: 25,644 Da
Evidence: 1: Evidence at protein level

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser…

3D-structureCell membraneCytokineDirect protein sequencingDisulfide bondGlycoproteinLipoproteinMembrane

View on UniProt →

Swiss-Prot (reviewed) · via UniProt

Clinical Trials

489 registered

COMPLETED
Safety and Effectiveness of Adalimumab in Patients Diagnosed With Rheumatoid ArthritisAbbott · NCT01078571
PHASE3COMPLETED
Melphalan With or Without Tumor Necrosis Factor in Treating Patients With Locally Advanced Melanoma of the Arm or LegNational Cancer Institute (NCI) · NCT00003789
COMPLETED
TNFα and MFG-E8: Novel Biomarkers to Predict Implantation FailureEastern Virginia Medical School · NCT02386384
NACOMPLETED
A Study to Evaluate the Ability of TNFR:Fc to Decrease the Amount of IL-6 (Interleukin-6) and TNF-alpha (Tumor Necrosis Factor) in HIV-Infected PatientsNational Institute of Allergy and Infectious Diseases (NIAID) · NCT00001116
COMPLETED
On the Impact of Therapeutic Tumor Necrosis Factor-alpha Inhibition on Anogenital Human Papillomavirus InfectionMedical University of Vienna · NCT02376478
PHASE1/PHASE2ACTIVE_NOT_RECRUITING
BI-1910 as a Single Agent and in Combination With Pembrolizumab for the Treatment of Advanced Solid TumorsBioInvent International AB · NCT06205706

via ClinicalTrials.gov

Wikidata facts

Instance of: protein
Image: TNFa Crystal Structure.rsh.png

Show 3 more facts

cell component: extracellular space
Commons category: Tumor necrosis factor-alpha
found in taxon: Homo sapiens

Sources (5)

via Wikidata · CC0

~35 min read

Encyclopedic overview

Identifiers AliasesTNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, tumor necrosis factor, TNLG1F, Tumor necrosis factor alpha External IDsOMIM: 191160; MGI: 104798; HomoloGene: 496; GeneCards: TNF; OMA:TNF - orthologs

More reference expression data

Excerpted from Wikipedia’s “tumor necrosis factor” article, available under the CC BY-SA 4.0 licence.