TARDBP

Name

TAR DNA binding protein

Type

protein-coding

Position

11,012,344–11,037,991 (+)

Aliases

ALS10, TDP-43

Ensembl

ENSG00000120948

RefSeq RNA

NM_007375.4, XR_007058558.1, XR_007058559.1, XR_007058560.1, XR_007058561.1

RefSeq protein

NP_031401.1

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

TAR DNA binding protein

Symbol

TARDBP

Biotype

Protein coding

Organism

Homo sapiens

Location

1:11,012,344-11,037,991

Strand

Forward (+)

Assembly

GRCh38