TMEM106B
Sign in to saveAlso known as transmembrane protein 106B, HLD16
Transmembrane protein 106B is a protein that is encoded by the TMEM106B gene. It is found primarily within neurons and oligodendrocytes in the central nervous system with its subcellular location being in lysosomal membranes. TMEM106B helps facilitate important functions for maintaining a healthy lysosome, and therefore certain mutations and polymorphisms can lead to issues with proper lysosomal function. Lysosomes are in charge of clearing out mis-folded proteins and other debris, and thus, play an important role in neurodegenerative diseases that are driven by the accumulation of various mis
Gene data
TMEM106B- Name
- transmembrane protein 106B
- Type
- protein-coding
- Position
- 12,210,931–12,243,367 (+)
- Aliases
- HLD16
- Ensembl
- ENSG00000106460
- RefSeq RNA
- NM_001134232.2, NM_018374.4
- RefSeq protein
- NP_001127704.1, NP_060844.2
Enables ATPase binding activity. Involved in dendrite morphogenesis and lysosome localization. Located in endosome and lysosomal membrane. Implicated in hypomyelinating leukodystrophy. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
transmembrane protein 106B
- Symbol
- TMEM106B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:12,210,931-12,243,367
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~13 min read
Encyclopedic overview
20 sectionsContents
- Structure
- Gene
- Protein
- Fibrils
- Function
- Lysosomal size
- Lysosomal trafficking
- Lysosomal pH
- Clinical implications
- Frontotemporal dementia
- Amyotrophic lateral sclerosis
- Alzheimer's disease
- Chronic traumatic encephalopathy
- Parkinson disease
- Interactions
- Progranulin and granulin
- Vacuolar ATPase
- Microtubule associate protein 6
- References
- Further reading
Transmembrane protein 106B is a protein that is encoded by the TMEM106B gene. It is found primarily within neurons and oligodendrocytes in the central nervous system with its subcellular location being in lysosomal membranes. TMEM106B helps facilitate important functions for maintaining a healthy lysosome, and therefore certain mutations and polymorphisms can lead to issues with proper lysosomal function. Lysosomes are in charge of clearing out mis-folded proteins and other debris, and thus, play an important role in neurodegenerative diseases that are driven by the accumulation of various mis-folded proteins and aggregates. Due to its impact on lysosomal function, TMEM106B has been investigated and found to be associated to multiple neurodegenerative diseases.
== Structure ==
Excerpted from Wikipedia’s “TMEM106B” article, available under the CC BY-SA 4.0 licence.