tetanospasmin

Protein · UniProt

Tetanus toxin

Gene

tetX

Organism

Clostridium tetani (strain Massachusetts / E88)

Length

1,315 aa

Molecular mass

150,682 Da

Evidence

1: Evidence at protein level

Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2

• [Tetanus].Brain and nerve = Shinkei kenkyu no shinpo · 2026
• Tetanus neurotoxin.Toxicon : official journal of the International Society on Toxinology · 2013
• Tetanus.Kathmandu University medical journal (KUMJ) · 2009
• Tetanospasmin injection treating sleep disordered breathing.Medical hypotheses · 2008
• Tetanus.Comprehensive therapy · 1986

via PubMed