tetanospasmin
Sign in to saveAlso known as tetanus toxin, tetanus neurotoxin, spasmogenic toxin, TeNT
chemical compound
In the Vinony graph
Within Vinony's link graph, tetanospasmin is referenced by 450 other articles, and connects out to solasonine, PubMed and PubMed Central.
Vinony files it under Bacterial toxins, EC 3.4.24 and Membrane channels.
Its subject is documented across 24 Wikipedia language editions.
Protein · UniProt
Tetanus toxin
- Gene
- tetX
- Organism
- Clostridium tetani (strain Massachusetts / E88)
- Length
- 1,315 aa
- Molecular mass
- 150,682 Da
- Evidence
- 1: Evidence at protein level
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2
Swiss-Prot (reviewed) · via UniProt
Research
147 papers- [Tetanus].Brain and nerve = Shinkei kenkyu no shinpo · 2026
- Tetanus neurotoxin.Toxicon : official journal of the International Society on Toxinology · 2013
- Tetanus.Kathmandu University medical journal (KUMJ) · 2009
- Tetanospasmin injection treating sleep disordered breathing.Medical hypotheses · 2008
- Tetanus.Comprehensive therapy · 1986
via PubMed
Wikidata facts
- Instance of
- neurotoxin
Show 2 more facts
- EC enzyme number
- 3.4.24.68
- found in taxon
- Clostridium tetani
Sources (1)
via Wikidata · CC0