TGFBI

Also known as BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3

Transforming growth factor, beta-induced, 68kDa, also known as TGFBI (initially called BIGH3, BIG-H3), is a protein which in humans is encoded by the TGFBI gene, locus 5q31.

In the Vinony graph

Vinony's link graph records 13 inbound references to TGFBI, and connects out to PubMed, human chromosome 5 and Ensembl genome database project.

Vinony files it under Extracellular matrix proteins and Genes on human chromosome 5.

Vinony links it to 8 Wikipedia language editions.

Gene data

TGFBI

Name: transforming growth factor beta induced
Type: protein-coding
Position: 136,028,854–136,103,902 (+)
Aliases: BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1
Ensembl: ENSG00000120708
RefSeq RNA: NM_000358.3
RefSeq protein: NP_000349.1

This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008].

Pathways

Metabolism of proteins Amyloid fiber formation

via MyGene.info

Gene · Ensembl

transforming growth factor beta induced

Symbol: TGFBI
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:136,028,854-136,103,902
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein TGFBI PDB 1x3b.png

Show 8 more facts

HomoloGene ID: 37294
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/7045
genomic end: 135399507
genomic start: 136028988
chromosome: human chromosome 5
cytogenetic location: 5q31.1
expressed in: gallbladder

Sources (6)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
Clinical significance
References
Further reading

Transforming growth factor, beta-induced, 68kDa, also known as TGFBI (initially called BIGH3, BIG-H3), is a protein which in humans is encoded by the TGFBI gene, locus 5q31.

== Function ==

Excerpted from Wikipedia’s “TGFBI” article, available under the CC BY-SA 4.0 licence.