TGFBI
Sign in to saveAlso known as BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3
Transforming growth factor, beta-induced, 68kDa, also known as TGFBI (initially called BIGH3, BIG-H3), is a protein which in humans is encoded by the TGFBI gene, locus 5q31.
Gene data
TGFBI- Name
- transforming growth factor beta induced
- Type
- protein-coding
- Position
- 136,028,988–136,063,818 (+)
- Aliases
- BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1
- Ensembl
- ENSG00000120708
- RefSeq RNA
- NM_000358.3
- RefSeq protein
- NP_000349.1
This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Wikidata facts
- Image
- Protein TGFBI PDB 1x3b.png
Show 5 more facts
- HomoloGene ID
- 37294
- exact match
- identifiers.org/ncbigene/7045
- genomic end
- 135399507
- genomic start
- 136028988
- cytogenetic location
- 5q31.1
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
Transforming growth factor, beta-induced, 68kDa, also known as TGFBI (initially called BIGH3, BIG-H3), is a protein which in humans is encoded by the TGFBI gene, locus 5q31.
== Function ==