TIMP3
Sign in to saveAlso known as HSMRK222, K222, K222TA2, SFD, TIMP metallopeptidase inhibitor 3
gene umano
Gene data
TIMP3- Name
- TIMP metallopeptidase inhibitor 3
- Type
- protein-coding
- Position
- 32,801,576–32,863,042 (+)
- Aliases
- HSMRK222, K222, K222TA2, SFD
- Ensembl
- ENSG00000100234
- RefSeq RNA
- NM_000362.5
- RefSeq protein
- NP_000353.1
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
response to hormonenegative regulation of extracellular matrix disassemblynegative regulation of extracellular matrix disassemblyresponse to cytokinenegative regulation of proteolysisnegative regulation of membrane protein ectodomain proteolysisnegative regulation of membrane protein ectodomain proteolysis
Molecular function
Pathways
Proteoglycans in cancer - Homo sapiens (human)MicroRNAs in cancer - Homo sapiens (human)HemostasisPlatelet degranulation Platelet activation, signaling and aggregationResponse to elevated platelet cytosolic Ca2+Matrix MetalloproteinasesAngiogenesisOncostatin M Signaling PathwayVitamin D Receptor Pathway
via MyGene.info
Gene · Ensembl
TIMP metallopeptidase inhibitor 3
- Symbol
- TIMP3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:32,801,576-32,863,042
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 36322
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/7078
- genomic end
- 32863041
- genomic start
- 32801705
- chromosome
- human chromosome 22
- cytogenetic location
- 22q12.3
Sources (7)
via Wikidata · CC0