Structure via PubChem · Public domain (PubChem)
tolimidone
Sign in to saveTolimidone (CP-26154; MLR-1023) is a compound which was discovered by scientists at Pfizer, was found to stimulate secretion of gastric mucosa, and was in development by Pfizer as a drug candidate to treat gastric ulcers but was abandoned. After the patent on the compound expired, scientists at the company Melior Discovery identified it as a potential drug candidate for diabetes through a phenotypic screen. The company proceeded to show that MLR-1023 is an allosteric activator of Lyn kinase with an EC50 of 63 nM. As of 2012 Melior was repurposing it for diabetes. In June 2016, the company repo
Chemical data
- Formula
- C11H10N2O2
- Molecular weight
- 202.21 g/mol
- IUPAC name
- 5-(3-methylphenoxy)-1H-pyrimidin-2-one
- SMILES
- CC1=CC(=CC=C1)OC2=CNC(=O)N=C2
- InChIKey
- HJQILFPVRNHTIG-UHFFFAOYSA-N
- XLogP
- 1.4
- Polar surface area
- 50.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- type 2 diabetes mellitus
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 202.074
Show 2 more facts
- chemical formula
- C₁₁H₁₀N₂O₂
- canonical SMILES
- CC1=CC(=CC=C1)OC2=CNC(=O)N=C2
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Tolimidone (CP-26154; MLR-1023) is a compound which was discovered by scientists at Pfizer, was found to stimulate secretion of gastric mucosa, and was in development by Pfizer as a drug candidate to treat gastric ulcers but was abandoned. After the patent on the compound expired, scientists at the company Melior Discovery identified it as a potential drug candidate for diabetes through a phenotypic screen. The company proceeded to show that MLR-1023 is an allosteric activator of Lyn kinase with an EC50 of 63 nM. As of 2012 Melior was repurposing it for diabetes. In June 2016, the company reported positive results from their Phase 2a clinical study in diabetic subjects
== References ==
Excerpted from Wikipedia’s “tolimidone” article, available under the CC BY-SA 4.0 licence.