Structure via PubChem · Public domain (PubChem)
tozasertib
Sign in to saveAlso known as MK 0457, VX 680, VX-680
Tozasertib (VX-680) is an aurora inhibitor.
Chemical data
- Formula
- C23H28N8OS
- Molecular weight
- 464.6 g/mol
- IUPAC name
- N-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide
- SMILES
- CC1=CC(=NN1)NC2=CC(=NC(=N2)SC3=CC=C(C=C3)NC(=O)C4CC4)N5CCN(CC5)C
- InChIKey
- GCIKSSRWRFVXBI-UHFFFAOYSA-N
- XLogP
- 3.4
- Polar surface area
- 127 Ų
- H-bond donors
- 3
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- leukemia, non-small cell lung carcinoma, myelodysplastic syndrome, acute lymphoblastic leukemia
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 464.211
Show 2 more facts
- chemical formula
- C₂₃H₂₈N₈OS
- canonical SMILES
- CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
{{chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 449871325 | ImageFile=Tozasertib.svg | ImageClass = skin-invert-image | ImageSize=200px | PIN=N-[4-({4-(4-Methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide | OtherNames= |Section1= |Section2= |Section3= }}
Tozasertib (VX-680) is an aurora inhibitor.
Excerpted from Wikipedia’s “tozasertib” article, available under the CC BY-SA 4.0 licence.