TRIM21
Sign in to saveAlso known as RNF81, RO52, Ro/SSA, SSA, SSA1, tripartite motif containing 21, Tripartite motif-containing protein 21
Tripartite motif-containing protein 21, also known as E3 ubiquitin-protein ligase TRIM21, is a protein that in humans is encoded by the TRIM21 gene. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. It is expressed in most human tissues.
Gene data
TRIM21- Name
- tripartite motif containing 21
- Type
- protein-coding
- Position
- 4,384,897–4,393,747 (−)
- Aliases
- RNF81, RO52, Ro/SSA, SSA, SSA1, TRIM21/Ro52
- Ensembl
- ENSG00000132109
- RefSeq RNA
- NM_003141.4
- RefSeq protein
- NP_003132.2
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
tripartite motif containing 21
- Symbol
- TRIM21
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:4,384,897-4,393,747
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- E3 ubicuitina-proteína ligasa Trim21. Generado con IA..png
Show 7 more facts
- HomoloGene ID
- 2365
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6737
- genomic end
- 4393702
- genomic start
- 4406127
- chromosome
- human chromosome 11
- cytogenetic location
- 11p15.4
Sources (4)
via Wikidata · CC0
~2 min read
Encyclopedic overview
5 sectionsContents
- Structure
- Function
- Clinical significance
- References
- Further reading
Tripartite motif-containing protein 21, also known as E3 ubiquitin-protein ligase TRIM21, is a protein that in humans is encoded by the TRIM21 gene. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. It is expressed in most human tissues.
==Structure== TRIM21 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING finger domain, a B-box type 1 and a B-box type 2 zinc finger, and a coiled coil region.
Excerpted from Wikipedia’s “TRIM21” article, available under the CC BY-SA 4.0 licence.