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GeneQ18032268· pop 6· linked from 109 articles

UBE2V2

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Also known as DDVIT1, DDVit-1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2

Ubiquitin-conjugating enzyme E2 variant 2 is a protein that in humans is encoded by the UBE2V2 gene. Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family.

Gene data

UBE2V2
Name
ubiquitin conjugating enzyme E2 V2
Type
protein-coding
Position
48,008,410–48,067,523 (+)
Aliases
DDVIT1, DDVit-1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2
Ensembl
ENSG00000169139
RefSeq RNA
NM_003350.3, XM_011517583.4, XM_017013808.3, XM_054361176.1, XM_054361177.1
RefSeq protein
NP_003341.1, XP_011515885.1, XP_016869297.2, XP_054217151.1, XP_054217152.1

Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008].

Gene Ontology

Molecular function

protein binding

Pathways

Shigellosis - Homo sapiens (human)Adaptive Immune SystemCell CycleImmune SystemMetabolism of proteinsDNA Double-Strand Break RepairHomology Directed RepairRecruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksHDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)Nonhomologous End-Joining (NHEJ)

via MyGene.info

Gene · Ensembl

ubiquitin conjugating enzyme E2 V2

Symbol
UBE2V2
Biotype
Protein coding
Organism
Homo sapiens
Location
8:48,008,410-48,067,523
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Image
Protein UBE2V2 PDB 1j74.png
Show 7 more facts
HomoloGene ID
55739
chromosome
human chromosome 8
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/7336
genomic start
48008415
genomic end
48977268
cytogenetic location
8q11.21
Sources (4)

via Wikidata · CC0

~3 min read

Encyclopedic overview

5 sections
Contents
  • Structure
  • Function
  • Interactions
  • References
  • Further reading

Ubiquitin-conjugating enzyme E2 variant 2 is a protein that in humans is encoded by the UBE2V2 gene. Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family.

== Structure ==

Excerpted from Wikipedia’s “UBE2V2” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0