TXNDC5
Sign in to saveAlso known as ENDOPDI, ERP46, HCC-2, PDIA15, STRF8, UNQ364, HCC2, thioredoxin domain containing 5
Thioredoxin domain-containing protein 5 is a protein that in humans is encoded by the TXNDC5 gene.
Gene data
TXNDC5- Name
- thioredoxin domain containing 5
- Type
- protein-coding
- Aliases
- ENDOPDI, ERP46, HCC-2, HCC2, PDIA15, STRF8, UNQ364
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016].
via MyGene.info
Wikidata facts
- Image
- Protein TXNDC5 PDB 2diz.png
Show 5 more facts
- HomoloGene ID
- 11125
- exact match
- identifiers.org/ncbigene/81567
- cytogenetic location
- 6p24.3
- genomic end
- 7910788
- genomic start
- 7881483
Sources (3)
via Wikidata · CC0
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Article
3 sectionsContents
- Function
- References
- Further reading
Thioredoxin domain-containing protein 5 is a protein that in humans is encoded by the TXNDC5 gene.
== Function ==