UBQLN1
Sign in to saveAlso known as DA41, DSK2, PLIC-1, UBQN, XDRP1, ubiquilin 1
Ubiquilin-1 is a protein that in humans is encoded by the UBQLN1 gene.
Gene data
UBQLN1- Name
- ubiquilin 1
- Type
- protein-coding
- Aliases
- DA41, DSK2, PLIC-1, UBQN, XDRP1
This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
via MyGene.info
Wikidata facts
- Image
- 2klc rainbow all states.png
Show 6 more facts
- HomoloGene ID
- 137258
- exact match
- identifiers.org/ncbigene/29979
- genomic end
- 83707958
- genomic start
- 83659968
- cytogenetic location
- 9q21.32|9q21.2-q21.3
- Commons category
- Ubiquilin-1
Sources (4)
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Article
5 sectionsContents
- Functions
- Related proteins
- Interactions
- References
- Further reading
Ubiquilin-1 is a protein that in humans is encoded by the UBQLN1 gene.
Ubiquilins contain two domains, an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to effect in vivo protein degradation.