UBQLN2
Sign in to saveAlso known as ALS15, CHAP1, DSK2, N4BP4, PLIC2, HRIHFB2157, ubiquilin 2
Ubiquilin-2 is a protein that in humans is encoded by the UBQLN2 gene.
Gene data
UBQLN2- Name
- ubiquilin 2
- Type
- protein-coding
- Chromosome
- X
- Position
- 56,563,627–56,567,868 (+)
- Aliases
- ALS15, CHAP1, DSK2, HRIHFB2157, N4BP4, PLIC2
- Ensembl
- ENSG00000188021
- RefSeq RNA
- NM_013444.4
- RefSeq protein
- NP_038472.2
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ubiquilin 2
- Symbol
- UBQLN2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr X:56,563,627-56,567,868
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein UBQLN2 PDB 1j8c.png
Show 8 more facts
- HomoloGene ID
- 81830
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/29978
- chromosome
- human X chromosome
- genomic end
- 56593443
- genomic start
- 56563627
- cytogenetic location
- Xp11.21
- expressed in
- middle temporal gyrus
Sources (6)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Similarity to other proteins
- Clinical significance
- Interactions
- References
- Further reading
Ubiquilin-2 is a protein that in humans is encoded by the UBQLN2 gene.
== Function ==
Excerpted from Wikipedia’s “UBQLN2” article, available under the CC BY-SA 4.0 licence.