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GeneQ18032299· pop 6· linked from 14 articles

UQCRFS1

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Also known as RIP1, RIS1, RISP, UQCR5, ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1, MC3DN10

Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1, also known as UQCRFS1, Rieske iron-sulfur (Fe-S) protein, Cytochrome b-c1 complex subunit 5, or Complex III subunit 5 is a protein which in humans is encoded by the UQCRFS1 gene. UQCRFS1 is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of both the product of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and the products of ten nuclear genes UQCRC1, UQCRC2, Cytochrome C1, UQCRFS1 (this protein, a type of Rieske pr

Gene data

UQCRFS1
Name
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
Type
protein-coding
Position
29,202,811–29,213,151 (−)
Aliases
ISP, MC3DN10, RIP1, RIS1, RISP, UQCR5
Ensembl
ENSG00000169021
RefSeq RNA
NM_006003.3
RefSeq protein
NP_005994.2

Predicted to enable oxidoreductase activity. Involved in mitochondrial respiratory chain complex III assembly and respiratory electron transport chain. Located in mitochondrion. Part of mitochondrial respiratory chain complex III and mitochondrial respiratory chain complex IV. Implicated in mitochondrial complex III deficiency. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Pathways

Oxidative phosphorylation - Homo sapiens (human)Cardiac muscle contraction - Homo sapiens (human)Thermogenesis - Homo sapiens (human)Non-alcoholic fatty liver disease - Homo sapiens (human)Alzheimer disease - Homo sapiens (human)Parkinson disease - Homo sapiens (human)Amyotrophic lateral sclerosis - Homo sapiens (human)Huntington disease - Homo sapiens (human)Prion disease - Homo sapiens (human)Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

Symbol
UQCRFS1
Biotype
Protein coding
Organism
Homo sapiens
Location
19:29,202,811-29,213,151
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Image
Protein UQCRFS1 PDB 1be3.png
Show 8 more facts
HomoloGene ID
4378
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/7386
genomic end
29213151
genomic start
29205320
chromosome
human chromosome 19
cytogenetic location
19q12
expressed in
rectum
Sources (4)

via Wikidata · CC0

~3 min read

Encyclopedic overview

6 sections
Contents
  • Structure
  • Function
  • Clinical significance
  • Interactions
  • References
  • Further reading

Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1, also known as UQCRFS1, Rieske iron-sulfur (Fe-S) protein, Cytochrome b-c1 complex subunit 5, or Complex III subunit 5 is a protein which in humans is encoded by the UQCRFS1 gene. UQCRFS1 is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of both the product of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and the products of ten nuclear genes UQCRC1, UQCRC2, Cytochrome C1, UQCRFS1 (this protein, a type of Rieske protein), UQCRB, ("11kDa protein"), UQCRH (cyt c1 Hinge protein), UCRC ("cyt. c1 associated protein"), and ("Rieske-associated protein").

== Structure ==

Excerpted from Wikipedia’s “UQCRFS1” article, available under the CC BY-SA 4.0 licence.

Available in 6 languages

via Wikidata sitelinks · CC0