UQCRC1

Also known as D3S3191, QCR1, UQCR1, ubiquinol-cytochrome c reductase core protein I, ubiquinol-cytochrome c reductase core protein 1, PKNPY

Cytochrome b-c1 complex subunit 1, mitochondrial is a protein that in humans is encoded by the UQCRC1 gene.

Gene data

UQCRC1

Name: ubiquinol-cytochrome c reductase core protein 1
Type: protein-coding
Position: 48,599,002–48,610,976 (−)
Aliases: D3S3191, PKNPY, QCR1, UQCR1
Ensembl: ENSG00000010256
RefSeq RNA: NM_003365.3, XM_054347744.1
RefSeq protein: NP_003356.2, XP_054203719.1

Enables ubiquitin protein ligase binding activity. Predicted to be involved in oxidative phosphorylation. Predicted to act upstream of or within mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Implicated in Alzheimer's disease. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]

Pathways

Oxidative phosphorylation - Homo sapiens (human)Cardiac muscle contraction - Homo sapiens (human)Thermogenesis - Homo sapiens (human)Non-alcoholic fatty liver disease - Homo sapiens (human)Alzheimer disease - Homo sapiens (human)Parkinson disease - Homo sapiens (human)Amyotrophic lateral sclerosis - Homo sapiens (human)Huntington disease - Homo sapiens (human)Prion disease - Homo sapiens (human)Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

ubiquinol-cytochrome c reductase core protein 1

Symbol: UQCRC1
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:48,598,990-48,610,976
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein UQCRC1 PDB 1be3.png

Show 8 more facts

HomoloGene ID: 2525
genomic end: 48648409
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/7384
genomic start: 48636435
chromosome: human chromosome 3
cytogenetic location: 3p21.31
expressed in: vastus lateralis muscle

Sources (4)

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Encyclopedic overview

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Contents

References
Further reading

Cytochrome b-c1 complex subunit 1, mitochondrial is a protein that in humans is encoded by the UQCRC1 gene.

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and Rieske-associated protein.

Excerpted from Wikipedia’s “UQCRC1” article, available under the CC BY-SA 4.0 licence.