UQCRQ

Also known as MC3DN4, QCR8, QP-C, QPC, UQCR7, ubiquinol-cytochrome c reductase complex III subunit VII

Ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa is a protein that in humans is encoded by the UQCRQ gene. This ubiqinone-binding protein is a subunit of mitochondrial Complex III in the electron transport chain. A mutation in the UQCRQ gene has been shown to cause severe neurological disorders. Infection by Trypanosoma cruzi can cause oxidative modification of this protein in cardiac muscle tissue.

Gene data

UQCRQ

Name: ubiquinol-cytochrome c reductase complex III subunit VII
Type: protein-coding
Position: 132,866,623–132,868,847 (+)
Aliases: MC3DN4, QCR8, QP-C, QPC, UQCR7
Ensembl: ENSG00000164405
RefSeq RNA: NM_014402.5
RefSeq protein: NP_055217.2

This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

mitochondrial electron transport, ubiquinol to cytochrome c mitochondrial electron transport, ubiquinol to cytochrome c mitochondrial electron transport, ubiquinol to cytochrome c subthalamus development pons development cerebellar Purkinje cell layer development hippocampus development thalamus development

Cellular component

mitochondrion mitochondrion mitochondrion mitochondrial inner membrane mitochondrial inner membrane mitochondrial inner membrane mitochondrial inner membrane mitochondrial inner membrane

Pathways

Oxidative phosphorylation - Homo sapiens (human)Cardiac muscle contraction - Homo sapiens (human)Thermogenesis - Homo sapiens (human)Non-alcoholic fatty liver disease - Homo sapiens (human)Alzheimer disease - Homo sapiens (human)Parkinson disease - Homo sapiens (human)Amyotrophic lateral sclerosis - Homo sapiens (human)Huntington disease - Homo sapiens (human)Prion disease - Homo sapiens (human)Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

ubiquinol-cytochrome c reductase complex III subunit VII

Symbol: UQCRQ
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:132,866,623-132,868,847
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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Encyclopedic overview

6 sections

Contents

Structure
Function
Clinical significance
Interactions
References
Further reading

== Structure == The UQCRQ gene is located on the q arm of chromosome 5 in position 31.1 and spans 2,217 base pairs. The gene produces a 9.9 kDa protein composed of 82 amino acids. This protein is transmembranous, with more mass on the matrix side of the membrane.

Excerpted from Wikipedia’s “UQCRQ” article, available under the CC BY-SA 4.0 licence.