VPS25
Sign in to saveAlso known as DERP9, EAP20, FAP20, vacuolar protein sorting 25 homolog
Vacuolar protein-sorting-associated protein 25 is a protein that in humans is encoded by the VPS25 gene.
Gene data
VPS25- Name
- vacuolar protein sorting 25 homolog
- Type
- protein-coding
- Aliases
- DERP9, EAP20, FAP20
This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Jul 2013].
via MyGene.info
Gene · Ensembl
vacuolar protein sorting 25 homolog
- Symbol
- VPS25
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:42,773,439-42,779,600
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein VPS25 PDB 2ZME.png
Show 5 more facts
- HomoloGene ID
- 6303
- exact match
- identifiers.org/ncbigene/84313
- genomic start
- 42773449
- genomic end
- 40931617
- cytogenetic location
- 17q21.2
Sources (4)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Vacuolar protein-sorting-associated protein 25 is a protein that in humans is encoded by the VPS25 gene.
It is a component of the endosome-associated complex ESCRT-II (Endosomal Sorting Complexes Required for Transport protein II). ESCRT (ESCRT-I, -II, -III) complexes orchestrate efficient sorting of ubiquitinated transmembrane receptors to lysosomes via multivesicular bodies (MVBs). ESCRT-II recruits the transport machinery for protein sorting at MVB. In addition, the human ESCRT-II has been shown to form a complex with RNA polymerase II elongation factor ELL in order to exert transcriptional control activity. ESCRT-II transiently associates with the endosomal membrane and thereby initiates the formation of ESCRT-III, a membrane-associated protein complex that functions immediately downstream of ESCRT-II during sorting of MVB cargo. ESCRT-II in turn functions downstream of ESCRT-I, a protein complex that binds to ubiquitinated endosomal cargo.