VPS37A
Sign in to saveAlso known as HCRP1, PQBP2, SPG53, VPS37A, ESCRT-I subunit
Vacuolar protein sorting 37 homolog A (S. cerevisiae) is a protein in humans that is encoded by the VPS37A gene. It is a member of the endosomal sorting complex required for transport (ESCRT) system.
Gene data
VPS37A- Name
- VPS37A subunit of ESCRT-I
- Type
- protein-coding
- Position
- 17,246,896–17,333,474 (+)
- Aliases
- HCRP1, PQBP2, SPG53
- Ensembl
- ENSG00000155975
- RefSeq RNA
- NM_001145152.2, NM_001363167.1, NM_001363168.1, NM_001363169.1, NM_001363170.1
- RefSeq protein
- NP_001138624.1, NP_001350096.1, NP_001350097.1, NP_001350098.1, NP_001350099.1
This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
VPS37A subunit of ESCRT-I
- Symbol
- VPS37A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:17,246,896-17,333,474
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
3 sectionsContents
- Clinical significance
- References
- Further reading
Vacuolar protein sorting 37 homolog A (S. cerevisiae) is a protein in humans that is encoded by the VPS37A gene. It is a member of the endosomal sorting complex required for transport (ESCRT) system.
== Clinical significance ==
Excerpted from Wikipedia’s “VPS37A” article, available under the CC BY-SA 4.0 licence.