WFDC2
Sign in to saveAlso known as EDDM4, HE4, WAP5, dJ461P17.6, WAP four-disulfide core domain 2
WAP four-disulfide core domain protein 2 - also known as Human Epididymis Protein 4 (HE4) - is a protein that in humans is encoded by the WFDC2 gene.
In the Vinony graph
Vinony's link graph records 3 inbound references to WFDC2, and connects out to PubMed, human chromosome 20 and Ensembl genome database project.
It is catalogued under topics including Biomarkers and Genes on human chromosome 20.
Vinony links it to 7 Wikipedia language editions.
Gene data
WFDC2- Name
- WAP four-disulfide core domain 2
- Type
- protein-coding
- Position
- 45,469,166–45,481,533 (+)
- Aliases
- BENP, EDDM4, HE4, WAP5, dJ461P17.6
- Ensembl
- ENSG00000101443
- RefSeq RNA
- NM_006103.4, NM_080733.1, NM_080734.1, NM_080735.1, NM_080736.1
- RefSeq protein
- NP_006094.3
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
WAP four-disulfide core domain 2
- Symbol
- WFDC2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:45,469,166-45,481,533
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 4450
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10406
- genomic start
- 45469753
- cytogenetic location
- 20q13.12
- genomic end
- 44110172
- chromosome
- human chromosome 20
- expressed in
- trachea
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
WAP four-disulfide core domain protein 2 - also known as Human Epididymis Protein 4 (HE4) - is a protein that in humans is encoded by the WFDC2 gene.
HE4 is a tumor marker of ovarian cancer, with 80% sensitivity and 99% specificity at a cut-off of 150 pmol/L.
Excerpted from Wikipedia’s “WFDC2” article, available under the CC BY-SA 4.0 licence.