Genes on human chromosome 20

Oxytocin is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. Present in animals since early stages of evolution, in humans it plays roles in behavior that include social bonding, love, reproduction, childbirth, and the period after childbirth. Oxytocin is released into the bloodstream as a hormone in response to sexual activity and during childbirth. It is also available in pharmaceutical form. In either form, oxytocin stimulates uterine contractions to speed up the process of childbirth.

Mammalian vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the AVP gene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It then travels down the axon terminating in the posterior pituitary, and is released from vesicles into the circulation in response to extracellular fluid hypertonicity (hyperosmolality). AVP has two primary functions. First, it increases the amount of solute-free water reabsorbed back into the circulation from the filtrate in the kidney tubules of the nephrons. Seco

human chromosome

mammalian protein found in Homo sapiens

class of enzymes

Endothelins are peptides with receptors and effects in many body organs. Endothelin constricts blood vessels and raises blood pressure. The endothelins are normally kept in balance by other mechanisms, but when overexpressed, they contribute to high blood pressure (hypertension), heart disease, and potentially other diseases.

class of enzymes

Dynorphins (Dyn) are a class of opioid peptides that arise from the precursor protein prodynorphin. When prodynorphin is cleaved during processing by proprotein convertase 2 (PC2), multiple active peptides are released: dynorphin A, dynorphin B, and α/β-neoendorphin. Depolarization of a neuron containing prodynorphin stimulates PC2 processing, which occurs within synaptic vesicles in the presynaptic terminal. Occasionally, prodynorphin is not fully processed, leading to the release of big dynorphin, a 32-amino acid molecule consisting of both dynorphin A and dynorphin B.

mammalian protein found in Homo sapiens

mammalian protein found in Homo sapiens

class of enzymes

protein complex which is capable of increasing the processivity of nucleotide polymerization by DNA polymerase as a part of DNA replication

mammalian protein found in Homo sapiens

protein-coding gene in the species Homo sapiens

mammalian protein found in Homo sapiens

Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is also expressed on human mesothelial cell, monocyte and a dendritic cell subset.

protein-coding gene in the species Homo sapiens

mammalian protein found in Homo sapiens

protein-coding gene in the species Homo sapiens

Synaptosomal-Associated Protein, 25kDa (SNAP-25) is a Target Soluble NSF (N-ethylmaleimide-sensitive factor) Attachment Protein Receptor (t-SNARE) protein encoded by the SNAP25 gene found on chromosome 20p12.2 in humans. SNAP-25 is a component of the trans-SNARE complex, which accounts for membrane fusion specificity and directly executes fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes together.

protein family

protein-coding gene in the species Homo sapiens

Adenosylhomocysteinase (, S-adenosylhomocysteine synthase, S-adenosylhomocysteine hydrolase, adenosylhomocysteine hydrolase, S-adenosylhomocysteinase, SAHase, AdoHcyase) is an enzyme that catalyzes the nicotinamide adenine dinucleotide (NAD+) dependent, reversible hydrolysis of S-adenosylhomocysteine to homocysteine and adenosine.

mammalian protein found in Homo sapiens

class of enzymes

protein-coding gene in the species Homo sapiens

mammalian protein found in Homo sapiens

Jagged1 (JAG1) is one of five cell surface proteins (ligands) that interact with four receptors in the mammalian Notch signaling pathway. The Notch signaling pathway is a highly conserved pathway that functions to establish and regulate cell fate decisions in many organ systems. Once the JAG1-NOTCH (receptor-ligand) interactions take place, a cascade of proteolytic cleavages is triggered resulting in activation of the transcription for downstream target genes. Located on human chromosome 20, the JAG1 gene is expressed in multiple organ systems in the body and causes the autosomal dominant diso

Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.

CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene.

mammalian protein found in Homo sapiens

mammalian protein found in Homo sapiens

class of enzymes

cell surface protein binding somatostatin and triggering intracellular changes

protein-coding gene in the species Homo sapiens

YTH domain family, member 1 is a protein that in humans is encoded by the YTHDF1 gene.

Zinc finger protein 64 homolog, isoforms 1 and 2 is a protein that in humans is encoded by the ZFP64 gene.

protein-coding gene in the species Homo sapiens

Nucleolar protein 56 is a protein that in humans is encoded by the NOP56 gene.

thumb|Double-stranded RNA-binding protein Staufen homolog 1

Zinc fingers and homeoboxes protein 3 is a protein that in humans is encoded by the ZHX3 gene.

CD93 (Cluster of Differentiation 93) is a protein that in humans is encoded by the CD93 gene. CD93 is a C-type lectin transmembrane receptor which plays a role not only in cell–cell adhesion processes but also in host defense.

Targeting protein for Xklp2 is a protein that in humans is encoded by the TPX2 gene. It is one of the many spindle assembly factors that play a key role in inducing microtubule assembly and growth during M phase.

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

DEAD (Asp-Glu-Ala-Asp) box polypeptide 27, also known as DDX27, is a human gene.

Dysbindin domain-containing protein 2 is a protein that in humans is encoded by the DBNDD2 gene.

Inosine triphosphate pyrophosphatase is an enzyme that in humans is encoded by the ITPA gene, by the rdgB gene in bacteria E.coli and the HAM1 gene in yeast S. cerevisiae; the protein is also encoded by some RNA viruses of the Potyviridae family. Two transcript variants encoding two different isoforms have been found for this gene. Also, at least two other transcript variants have been identified which are probably regulatory rather than protein-coding.

Lethal(3)malignant brain tumor-like protein is a protein that in humans is encoded by the L3MBTL gene.

RNA-binding protein 39 is a protein that in humans is encoded by the RBM39 gene.

MROH8 is a protein in humans that is encoded by the MROH8 gene.

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

Engulfment and cell motility protein 2 is a protein that in humans is encoded by the ELMO2 gene.

protein-coding gene in the species Homo sapiens

mammalian protein found in Homo sapiens

DNA (cytosine-5)-methyltransferase 3 beta, is an enzyme that in humans in encoded by the DNMT3B gene. Mutation in this gene are associated with immunodeficiency, centromere instability and facial anomalies syndrome.

Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene.

Cystatin-D is a protein that in humans is encoded by the CST5 gene.

Fermitin family homolog 1 is a protein that in humans is encoded by the FERMT1 gene.