Y-27632
Sign in to saveAlso known as Y27632, Y 27632, 4-[(1R)-1-aminoethyl]-N-pyridin-4-yl-1-cyclohexanecarboxamide, R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl
Y-27632 is a biochemical tool used in the study of the rho-associated protein kinase (ROCK) signaling pathways. Y-27632 selectively inhibits p160ROCK, although it does inhibit other protein kinases such as PKCs at higher concentrations.
Research
3,189 papers- Y-27632 targeting ROCK1&2 modulates cell growth, fibrosis and epithelial-mesenchymal transition in hyperplastic prostate by inhibiting β-catenin pathway.Molecular biomedicine · 2024
- Y-27632 acts beyond ROCK inhibition to maintain epidermal stem-like cells in culture.Journal of cell science · 2023
- Roles of Y-27632 on sheep sperm metabolism.Journal of animal science · 2024
- Y-27632, a Rho-kinase inhibitor, attenuates myocardial ischemia-reperfusion injury in rats.International journal of molecular medicine · 2019
- Y-27632 enables long-term expansion of mouse submandibular gland epithelial cells via inactivation of TGF-β1/CTGF/p38 and ROCK2/JNK signaling pathway.Journal of oral biosciences · 2024
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 247.168462
Show 4 more facts
- chemical formula
- C₁₄H₂₁N₃O
- isomeric SMILES
- C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N
- canonical SMILES
- CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N
- Commons category
- Y-27632
Sources (2)
via Wikidata · CC0
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Encyclopedic overview
1 sectionsContents
- References
Y-27632 is a biochemical tool used in the study of the rho-associated protein kinase (ROCK) signaling pathways. Y-27632 selectively inhibits p160ROCK, although it does inhibit other protein kinases such as PKCs at higher concentrations.
It has been studied for its effects on corneal endothelial cells (CECs) and cardiac stem cells (CSCs).
Excerpted from Wikipedia’s “Y-27632” article, available under the CC BY-SA 4.0 licence.