Z-DNA-binding protein 1 (also known as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1) is an intracellular protein in mammals that can activate an innate immune pathways to suppress the viral infection. ZENB1 senses left-handed (Z-form) double-helical Z-DNA and Z-RNA, which are pathogen-associated molecular patterns (PAMPs). It associates with Receptor Interacting Protein Kinase 3 (RIPK3) to initiate PANoptosis, a form of inflammatory programmed cell death.
This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
via MyGene.info
Z-DNA-binding protein 1 (also known as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1) is an intracellular protein in mammals that can activate an innate immune pathways to suppress the viral infection. ZENB1 senses left-handed (Z-form) double-helical Z-DNA and Z-RNA, which are pathogen-associated molecular patterns (PAMPs). It associates with Receptor Interacting Protein Kinase 3 (RIPK3) to initiate PANoptosis, a form of inflammatory programmed cell death.
During infection of human cells with influenza A virus (IAV) and HSV-1, host cell-derived Z-RNAs, arising from viral disruption of host transcription termination, are detected by ZBP1 to initiate NF-κB signalling and PANoptosis.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).