ZIC1

Also known as ZIC, ZNF201, CRS6, Zic family member 1, BAIDCS

ZIC1 is a member of the Zinc finger of the cerebellum (ZIC) protein family.

Gene data

ZIC1

Name: Zic family zinc finger 1
Type: protein-coding
Position: 147,393,422–147,510,293 (+)
Aliases: BAIDCS, CRS6, ZIC, ZNF201
Ensembl: ENSG00000152977
RefSeq RNA: NM_003412.4
RefSeq protein: NP_003403.2

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

regulation of transcription by RNA polymerase II pattern specification process pattern specification process central nervous system development brain development brain development regulation of smoothened signaling pathway regulation of smoothened signaling pathway

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity DNA-binding transcription factor activity

Cellular component

nucleus nucleus nucleus nucleoplasm cytoplasm

Pathways

Developmental Biology Developmental Biology MITF-M-regulated melanocyte development Gastrulation Specification of the neural plate border Transcriptional and post-translational regulation of MITF-M expression and activity Neural Crest Differentiation Differentiation of white and brown adipocyte

via MyGene.info

Gene · Ensembl

Zic family zinc finger 1

Symbol: ZIC1
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:147,393,422-147,510,293
Strand: Forward (+)
Assembly: GRCh38

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Encyclopedic overview

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Contents

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Further reading

ZIC1 is a member of the Zinc finger of the cerebellum (ZIC) protein family.

ZIC1 is classified as a ZIC protein due to conservation of the five C2H2 zinc fingers, which enables the protein to interact with DNA and proteins. ZIC1 is found in close genomic configuration in another member of this protein family, ZIC4. Correct function of these proteins is critical for early development, and as such mutations of the genes encoding these proteins is known to result in various congenital defects. For example, if function of both ZIC1 and ZIC4 is lost (which can occur via an interstitial deletion due to their adjacent location) then this may result in the Dandy–Walker malformation.

Excerpted from Wikipedia’s “ZIC1” article, available under the CC BY-SA 4.0 licence.

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Dandy-Walker syndrome