GLI1
Sign in to saveAlso known as GLI, GLI family zinc finger 1, PAPA8, PPD1
Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated from human glioblastoma cells.
Gene data
GLI1- Name
- GLI family zinc finger 1
- Type
- protein-coding
- Position
- 57,459,783–57,472,268 (+)
- Aliases
- GLI, PAPA8, PPD1
- Ensembl
- ENSG00000111087
- RefSeq RNA
- NM_001160045.2, NM_001167609.2, NM_005269.3, XM_011538189.3, XM_011538190.3
- RefSeq protein
- NP_001153517.1, NP_001161081.1, NP_005260.1, XP_011536491.1, XP_011536492.1
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
GLI family zinc finger 1
- Symbol
- GLI1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:57,459,783-57,472,268
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein GLI1 PDB 2gli.png
Show 7 more facts
- found in taxon
- Homo sapiens
- HomoloGene ID
- 3859
- exact match
- identifiers.org/ncbigene/2735
- genomic end
- 57472268
- genomic start
- 57459785
- chromosome
- human chromosome 12
- cytogenetic location
- 12q13.3
via Wikidata · CC0
~5 min read
Encyclopedic overview
6 sectionsContents
- Function
- Gli family
- Isolation
- Interactions
- References
- External links
Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated from human glioblastoma cells.
== Function == The Gli proteins are the effectors of Hedgehog (Hh) signaling and have been shown to be involved in cell fate determination, proliferation and patterning in many cell types and most organs during embryo development. In the developing spinal cord the target genes of Gli proteins, that are themselves transcription factors, are arranged into a complex gene regulatory network that translates the extracellular concentration gradient of Sonic hedgehog into different cell fates along the dorsoventral axis.
Excerpted from Wikipedia’s “GLI1” article, available under the CC BY-SA 4.0 licence.