1-Aziridinyl compounds

Thiotepa (N,N',N''(-triethylenethiophosphoramide, INN), sold under the brand name Tepadina among others, is an anti-cancer medication.

Carboquone is a drug used in chemotherapy.

Triaziquone is a drug used in chemotherapy.

Triethylenemelamine (abbreviated TEM, also called Tretamine) is a drug used in chemotherapy.

Apaziquone (tentative trade name EOquin) is an indolequinone that is a bioreductive prodrug similar to the older chemotherapeutic agent mitomycin C. In hypoxic cells, such as those on the inner surface of the urinary bladder, apaziquone is converted to active metabolites by intracellular reductases. The active metabolites alkylate DNA and lead to apoptosis. This activity is preferentially expressed in neoplastic cells.