Structure via PubChem · Public domain (PubChem)
thiotepa
Sign in to saveThiotepa (N,N',N''(-triethylenethiophosphoramide, INN), sold under the brand name Tepadina among others, is an anti-cancer medication.
Chemical data
- Formula
- C6H12N3PS
- Molecular weight
- 189.22 g/mol
- IUPAC name
- tris(aziridin-1-yl)-sulfanylidene-lambda5-phosphane
- SMILES
- C1CN1P(=S)(N2CC2)N3CC3
- InChIKey
- FOCVUCIESVLUNU-UHFFFAOYSA-N
- XLogP
- 0.5
- Polar surface area
- 41.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
3,849 papers- Thiotepa.IARC monographs on the evaluation of carcinogenic risks to humans · 1990
- Revisiting intrathecal thiotepa: Efficacy and safety in secondary CNS malignancies.Medical oncology (Northwood, London, England) · 2024
- Thiotepa.Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses · 1991
- Thiotepa.Report on carcinogens : carcinogen profiles · 2011
- Thiotepa-induced leukoderma.Archives of dermatology · 1979
via PubMed
~18 min read
Encyclopedic overview
14 sectionsContents
- History
- Structure
- Reactivity
- Synthesis
- Medical uses
- Administration
- Clinical outcomes
- Metabolism
- Molecular mechanism of action
- Toxicity
- Myelosuppression
- Additional toxic effects
- Drug interactions
- References
Thiotepa (N,N',N''(-triethylenethiophosphoramide, INN), sold under the brand name Tepadina among others, is an anti-cancer medication.
Thiotepa is an organophosphorus compound with the formula (C2H4N)3PS.
Excerpted from Wikipedia’s “thiotepa” article, available under the CC BY-SA 4.0 licence.