Acetylcholinesterase inhibitors

Metolcarb (chemical formula: C9H11NO2) is a chemical compound used as an acaricide and an insecticide.

Formetanate is an insecticide and acaricide. It is used on alfalfa grown for seed and on some fruits, including citrus, pome, and stone fruits.

EA-4056 is a deadly carbamate nerve agent. It is lethal because it inhibits acetylcholinesterase. Inhibition causes an overly high accumulation of acetylcholine between the nerve and muscle cells. This paralyzes the muscles by preventing their relaxation. The paralyzed muscles include those used for breathing.

EA-2613 is an extremely toxic organophosphate nerve agent. It is an extremely potent acetylcholinesterase inhibitor that is resistant to atropine and oxime treatment.

EA-2098 is an extremely toxic organophosphate nerve agent. It is an extremely potent acetylcholinesterase inhibitor that is resistant to atropine and oxime treatment.

Demephion is an organothiophosphate insecticide. It is a mixture of two closely related structural isomers demephion-O and demephion-S.

Fluorotabun is a highly toxic organophosphate nerve agent of the G-series. It is the fluorinated analog of tabun, i.e. the cyanide group is replaced by a fluorine atom.

BAY-29952 is a broad spectrum insecticide. It is listed as an extremely hazardous substance according to the U.S. Emergency Planning and Community Right-to-Know Act.

Prothoate is an organothiophosphate insecticide also used as an acaricide.

A-242 is an organophosphate nerve agent. It was developed in the Soviet Union under the FOLIANT program and is one of the group of compounds referred to as Novichok agents that were revealed by Vil Mirzayanov. Mirzayanov gives little specific information about A-242, stating that it is highly toxic but no figures are given to compare it to other related agents. It is reportedly a solid rather than a volatile liquid as with most nerve agents, and in order to weaponise it successfully, it had to be milled into a fine powder form that could be dispersed as a dust.

Tebupirimfos, also known as phostebupirim, is an organothiophosphate insecticide. It is used on corn crops, including popcorn.

Demeton, sold as an amber oily liquid with a sulphur like odour under the name Systox, is an organophosphate derivative causing irritability and shortness of breath to individuals repeatedly exposed. It was used as a phosphorothioate insecticide and acaricide and has the chemical formula C8H19O3PS2. Although it was previously used as an insecticide, it is now largely obsolete due to its relatively high toxicity to humans. Demeton consists of two components, demeton-S and demeton-O in a ratio of approximately 2:1 respectively. The chemical structure of demeton is closely related to military ner

Cymserine is a drug related to physostigmine, which acts as a reversible cholinesterase inhibitor, with moderate selectivity (15 times) for the plasma cholinesterase enzyme butyrylcholinesterase, and relatively weaker inhibition of the better-known acetylcholinesterase enzyme. This gives it a much more specific profile of effects that may be useful for treating Alzheimer's disease without producing side effects such as tremors, lacrimation, and salivation that are seen with the older nonselective cholinesterase inhibitors currently used for this application, such as donepezil.

A-262 is an organophosphate nerve agent. It was developed in the Soviet Union under the FOLIANT program and is one of the group of compounds referred to as Novichok agents that were revealed by Vil Mirzayanov. Mirzayanov gives little specific information about A-262, stating that it is highly toxic, but no figures are given to compare it to other related agents. It is reportedly a solid rather than a volatile liquid as with most nerve agents, and in order to weaponise it successfully, it had to be milled into a fine powder form that could be dispersed as a dust.

Miotine is an anticholinesterase drug. Miotine was the first synthetic carbamate that was used clinically.

α-Viniferin is a stilbene trimer. It can be isolated from Caragana chamlagu and from Caragana sinica and from the stem bark of Dryobalanops aromatica. It is also present in relation to resistance to Botrytis cinerea and Plasmopara viticola in Vitis vinifera and Vitis riparia. It has been shown to inhibit acetylcholinesterase.

Tetrachlorvinphos is an organophosphate insecticide used to kill fleas and ticks.

Endothion is an organic compound used as an insecticide and acaricides. It is part of the chemical class of organophosphorus compounds. It is generally described as white crystals with a slight odor. It is used as an insecticide, but not sold in the United States or Canada.

Dimetilan (chemical formula: C10H16N4O3) is a carbamate insecticide.

Oxydemeton-methyl is an organothiophosphate insecticide. It is primarily used to control aphids, mites, and thrips.

Butocarboxim is a carbamate insecticide. It is a structural isomer of aldicarb.

Corydaline is an acetylcholinesterase inhibitor isolated from Corydalis yanhusuo.

Diisopropylphosphate is an acetylcholinesterase inhibitor. It acts by covalently binding to acetylcholinesterase.

Ladostigil (developmental code name TV-3326) is a novel neuroprotective agent being investigated for the treatment of neurodegenerative disorders like Alzheimer's disease, Lewy body disease, and Parkinson's disease. It was developed from structural modification of rasagiline.

Phosfolan (chemical formula: C7H14NO3PS2) is a chemical compound used as an insecticide.

Corynoline is an acetylcholinesterase inhibitor isolated from Corydalis incisa.