Structure via PubChem · Public domain (PubChem)
ladostigil
Sign in to saveLadostigil (developmental code name TV-3326) is a novel neuroprotective agent being investigated for the treatment of neurodegenerative disorders like Alzheimer's disease, Lewy body disease, and Parkinson's disease. It was developed from structural modification of rasagiline.
In the Vinony graph
Within Vinony's link graph, ladostigil is referenced by 483 other articles, and connects out to botulinum toxin group, enzyme inhibitor and L-tyrosine.
It is catalogued under topics including 1-Aminoindanes, Acetylcholinesterase inhibitors and Carbamates.
Its subject is documented across 4 Wikipedia language editions.
Chemical data
- Formula
- C16H20N2O2
- Molecular weight
- 272.34 g/mol
- IUPAC name
- [(3R)-3-(prop-2-ynylamino)-2,3-dihydro-1H-inden-5-yl] N-ethyl-N-methylcarbamate
- SMILES
- CCN(C)C(=O)OC1=CC2=C(CC[C@H]2NCC#C)C=C1
- InChIKey
- LHXOCOHMBFOVJS-OAHLLOKOSA-N
- XLogP
- 2
- Polar surface area
- 41.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- Dementia
via ChEMBL · EBI
Wikidata facts
- Mass
- 272.152
Show 4 more facts
- Commons category
- Ladostigil
- chemical formula
- C₁₆H₂₀N₂O₂
- canonical SMILES
- CCN(C)C(=O)OC1=CC2=C(CCC2NCC#C)C=C1
- isomeric SMILES
- CCN(C)C(=O)OC1=CC2=C(CC[C@H]2NCC#C)C=C1
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Ladostigil (developmental code name TV-3326) is a novel neuroprotective agent being investigated for the treatment of neurodegenerative disorders like Alzheimer's disease, Lewy body disease, and Parkinson's disease. It was developed from structural modification of rasagiline.
The drug acts as a reversible acetylcholinesterase and butyrylcholinesterase inhibitor, and an irreversible monoamine oxidase B inhibitor, and combines the mechanisms of action of older drugs like rivastigmine and rasagiline into a single molecule. In addition to its neuroprotective properties, ladostigil enhances the expression of neurotrophic factors like GDNF and BDNF, and may be capable of reversing some of the damage seen in neurodegenerative diseases via the induction of neurogenesis. Ladostigil also has antidepressant-like effects in animals, and may be useful for treating comorbid depression and anxiety often seen in such diseases as well.
Excerpted from Wikipedia’s “ladostigil” article, available under the CC BY-SA 4.0 licence.