Structure via PubChem · Public domain (PubChem)
corydaline
Sign in to saveAlso known as (13S,13aR)-2,3,9,10-tetramethoxy-13-methyl-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline, (+)-Corydaline
Corydaline is an acetylcholinesterase inhibitor isolated from Corydalis yanhusuo.
Chemical data
- Formula
- C22H27NO4
- Molecular weight
- 369.5 g/mol
- IUPAC name
- (13S,13aR)-2,3,9,10-tetramethoxy-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline
- SMILES
- C[C@@H]1[C@@H]2C3=CC(=C(C=C3CCN2CC4=C1C=CC(=C4OC)OC)OC)OC
- InChIKey
- VRSRXLJTYQVOHC-YEJXKQKISA-N
- XLogP
- 3.6
- Polar surface area
- 40.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
91 papers- Corydaline alleviates Parkinson's disease by regulating autophagy and GSK-3β phosphorylation.Psychopharmacology · 2024
- Corydaline binds to a druggable pocket of hEAG1 channel and inhibits hepatic carcinoma cell viability.European journal of pharmacology · 2024
- Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression.Journal of Asian natural products research · 2017
- Corydaline attenuates osteolysis in rheumatoid arthritis via mitigating reactive oxygen species production and suppressing calcineurin-Nfatc1 signaling.International immunopharmacology · 2024
- Corydaline and l-tetrahydropalmatine attenuate morphine-induced conditioned place preference and the changes in dopamine D(2) and GluA1 AMPA receptor expression in rats.European journal of pharmacology · 2020
via PubMed
Wikidata facts
- Mass
- 369.194
Show 4 more facts
- chemical formula
- C₂₂H₂₇NO₄
- isomeric SMILES
- C[C@@H]1[C@@H]2C3=CC(=C(C=C3CCN2CC4=C1C=CC(=C4OC)OC)OC)OC
- canonical SMILES
- CC1C2C3=CC(=C(C=C3CCN2CC4=C1C=CC(=C4OC)OC)OC)OC
- subject has role
- enzyme inhibitor
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Corydaline is an acetylcholinesterase inhibitor isolated from Corydalis yanhusuo.
Corydaline is a pharmacologically active isoquinoline alkaloid isolated from Corydalis tubers. It also has diverse biological activities. It exhibits the antiacetylcholinesterase(AChE; IC50 = 15 μM), antiallergic, antinociceptive, and gastric emptying activities.
Excerpted from Wikipedia’s “corydaline” article, available under the CC BY-SA 4.0 licence.