Cell cycle regulators

thumb|Tertiary structure of human cyclin A (lacking the amino-terminal 170 amino acids), showing the central core of two five-helix bundles, with additional helices at the amino terminus (black) and carboxyl terminus (grey). The yellow region in helix 1 is the MRAIL sequence or hydrophobic patch, which contributes to the recognition of some substrates. (PDB 1fin)

class of enzymes

A mitogen is a small bioactive protein or peptide that induces a cell to begin cell division, or enhances the rate of division (mitosis). Mitogenesis is the induction (triggering) of mitosis, typically via a mitogen.

mammalian protein found in Homo sapiens

p21Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, though is primarily associated with inhibition of CDK2. p21 represents a major target of p53 activity and thus is associated with linking DNA damage to cell cycle arrest. This protein is encoded by the CDKN1A gene located on chromosome 6 (6p21.2) in humans.

Cyclin-dependent kinase 4 inhibitor C is an enzyme that in humans is encoded by the CDKN2C gene.

mammalian protein found in Homo sapiens

Cyclin-dependent kinase inhibitor 1B (p27Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. It is often referred to as a cell cycle inhibitor protein because its major function is to stop or slow down the cell division cycle.

Cyclin-dependent kinases regulatory subunit 2 is a protein that in humans is encoded by the CKS2 gene.

Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

member of the cyclin family

Stathmin, also known as metablastin and oncoprotein 18 is a protein that in humans is encoded by the STMN1 gene.

Cyclin-L1 is a protein that in humans is encoded by the CCNL1 gene.

protein family

Cyclin-L2 is a protein that in humans is encoded by the CCNL2 gene. The protein encoded by this gene belongs to cyclin family.

Cyclin-dependent kinases regulatory subunit 1 is a protein that in humans is encoded by the CKS1B gene.

protein family

protein-coding gene in the species Homo sapiens

InterPro Family