CCNA1

Also known as CT146, Cyclin A1

protein-coding gene in the species Homo sapiens

Gene data

CCNA1

Name: cyclin A1
Type: protein-coding
Position: 36,431,520–36,442,870 (+)
Aliases: CT146
Ensembl: ENSG00000133101
RefSeq RNA: NM_001111045.4, NM_001111046.2, NM_001111047.2, NM_001413923.1, NM_003914.4
RefSeq protein: NP_001104515.2, NP_001104516.1, NP_001104517.1, NP_001400852.1, XP_011533596.1

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].