Complement system

part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promotes inflammation, and attacks the pathogen's cell membrane

series of chemical reactions which are initiated by a stimulus acting on a receptor that is transduced to the cell interior through second messengers and ultimately to effector molecules, resulting in a cell response to the initial stimulus

Anaphylatoxins, or complement peptides, are fragments (C3a, C4a and C5a) that are produced as part of the activation of the complement system. Complement components C3, C4 and C5 are large glycoproteins that have important functions in the immune response and host defense. They have a wide variety of biological activities and are proteolytically activated by cleavage at a specific site, forming a- and b-fragments. A-fragments form distinct structural domains of approximately 76 amino acids, coded for by a single exon within the complement protein gene. The C3a, C4a and C5a components are refer

protein complex produced by components of the complement cascade inserted into a target cell membrane and forming a pore

Properdin is a protein that in humans is encoded by the CFP (complement factor properdin) gene.

protein-coding gene in the species Homo sapiens

mammalian protein found in Homo sapiens

Basigin (BSG) also known as extracellular matrix metalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147) is a protein that in humans is encoded by the BSG gene. This protein is a determinant for the Ok blood group system. There are three known antigens in the Ok system; the most common being Oka (also called OK1), OK2 and OK3. Basigin has been shown to be an essential receptor on red blood cells for the human malaria parasite, Plasmodium falciparum. The common isoform of basigin (basigin-2) has two immunoglobulin domains, and the extended form basigin-1 has three.

C1-inhibitor (C1-inh, C1 esterase inhibitor) is a protease inhibitor belonging to the serpin superfamily. Its main function is the inhibition of the complement system (C1r, C1s) to prevent spontaneous activation but also as the major regulator of the contact system (PK, FXIIa, and FXIa).

Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

protein-coding gene in the species Homo sapiens

Complement C4-A is a kind of the Complement component 4 protein that in humans is encoded by the C4A gene.

Protein

mammalian protein found in Homo sapiens

class of enzymes

thumb|270px|Complement-pathways thumb|Complement system

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

mammalian protein found in Homo sapiens

protein involved in the intricate complement system

any immune system process involved in the activation of the alternative pathway of the complement cascade

protein fragment

class of receptor proteins

thumb|right|270px|The classical and alternative complement pathways. thumb|right|270px|Complement-pathways. C3 convertase (C4bC2b, formerly C4b2a) belongs to family of serine proteases and is necessary in innate immunity as a part of the complement system which eventuate in opsonisation of particles, release of inflammatory peptides, C5 convertase formation and cell lysis.

Pegcetacoplan, sold under the brand name Empaveli among others, is a medication used to treat paroxysmal nocturnal hemoglobinuria, geographic atrophy of the retina, glomerulopathy C3 and membranoproliferative globulonephritis. Pegcetacoplan is a complement inhibitor.

Lysis of a cell resulting from triggering of the complement cascade. An example can be seen with complement activation and subsequent lysis of a bacterial cell as a result of the binding of IgM to the cell surface followed by the binding of complemen

protein complex

protein-coding gene in the species Homo sapiens

mammalian protein found in Homo sapiens

protein family

protein-coding gene in the species Homo sapiens

instance of macromolecular complex in Homo sapiens with Reactome ID (R-HSA-173713)

activations of steps of the classical pathway of the complement cascade as immune process