CFP

Also known as BFD, PFC, PFD, PROPERDIN, complement factor properdin, properdin

Properdin is a protein that in humans is encoded by the CFP (complement factor properdin) gene.

Gene data

CFP

Name: complement factor properdin
Type: protein-coding
Chromosome: X
Position: 47,621,537–47,630,305 (−)
Aliases: BFD, PFC, PFD, PROPERDIN
Ensembl: ENSG00000126759
RefSeq RNA: NM_001145252.3, NM_002621.2
RefSeq protein: NP_001138724.1, NP_002612.1

This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009].

Gene Ontology

Biological process

immune response complement activation complement activation, alternative pathway defense response to bacterium positive regulation of complement activation, alternative pathway positive regulation of immune response protein stabilization positive regulation of opsonization

Molecular function

protein binding

Cellular component

extracellular region extracellular region extracellular region extracellular region endoplasmic reticulum lumen secretory granule specific granule lumen cytoplasmic side of Golgi membrane

Pathways

Herpes simplex virus 1 infection - Homo sapiens (human)Disease Complement cascade Initial triggering of complement Innate Immune System Immune System Alternative complement activation Activation of C3 and C5 Diseases of glycosylation Diseases associated with O-glycosylation of proteins

via MyGene.info

Gene · Ensembl

complement factor properdin

Symbol: CFP
Biotype: Protein coding
Organism: Homo sapiens
Location: Chr X:47,621,537-47,630,305
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Has part: carbon

Show 7 more facts

HomoloGene ID: 1969
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/5199
chromosome: human X chromosome
genomic start: 47623172
genomic end: 47489704
cytogenetic location: Xp11.23

Sources (6)

via Wikidata · CC0

~2 min read

Encyclopedic overview

6 sections

Contents

Structure
Function
History
Deficiency
References
External links

Properdin is a protein that in humans is encoded by the CFP (complement factor properdin) gene.

Properdin is plasma glycoprotein that activates the complement system of the innate immune system. This protein binds to bacterial cell walls and dying human cells to stabilize the C3 and C5-convertase enzyme complexes to form an attack complex that leads to the lysis of the cell.

Excerpted from Wikipedia’s “CFP” article, available under the CC BY-SA 4.0 licence.

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CFP