MASP2

Name

MBL associated serine protease 2

Type

protein-coding

Position

11,022,009–11,047,273 (−)

Aliases

MAP-2, MAP19, MASP-2, MASP1P1, sMAP

Ensembl

ENSG00000009724

RefSeq RNA

NM_006610.4, NM_139208.3, XM_017000097.1, XM_047439758.1, XM_054333925.1

RefSeq protein

NP_006601.2, NP_631947.1, XP_016855586.1, XP_047295714.1, XP_054189900.1

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].

via MyGene.info

Gene · Ensembl

MBL associated serine protease 2

Symbol

MASP2

Biotype

Protein coding

Organism

Homo sapiens

Location

1:11,022,009-11,047,273

Strand

Reverse (−)

Assembly

GRCh38