DNA-binding proteins

thumb|300px|Schematic representation of the assembly of the core histones into the nucleosome In biology, histones are highly-basic proteins abundant in lysine and arginine residues that are found in eukaryotic cell nuclei and in most Archaeal phyla. They act as spools around which DNA winds to create structural units called nucleosomes. Nucleosomes in turn are wrapped into 30-nanometer fibers that form tightly packed chromatin. Histones prevent DNA from becoming tangled and protect it from DNA damage. In addition, histones play important roles in gene regulation and DNA replication. Without h

thumb|300x300px|The lac operon: '''1: RNA Polymerase, 2: [[lac repressor, 3: Promoter, 4: Operator, 5: Lactose, 6: lacZ, 7: lacY, 8: lacA.'''

Protamines are small, arginine-rich, nuclear proteins that replace histones late in the haploid phase of spermatogenesis and are believed essential for sperm head condensation via genomic DNA compaction and stabilization. They may allow for denser packaging of DNA in the spermatozoon than histones, but they must be decompressed before the genetic data can be used for protein synthesis. However, part of the sperm's genome is packaged by histones (10-15% in humans and other primates) thought to bind genes that are essential for early embryonic development.

proteins that have DNA-binding domains and thus have a specific or general affinity for single- or double-stranded DNA

one of the five main histone proteins

enzyme complex

multisubunit complex that is located at the replication origins of a chromosome

MECP2 (methyl CpG binding protein 2) is a gene that encodes the protein MECP2. MECP2 appears to be essential for the normal function of nerve cells. The protein seems to be particularly important for mature nerve cells, where it is present in high levels. The MECP2 protein is likely to be involved in turning off ("repressing" or "silencing") several other genes. This prevents the genes from making proteins when they are not needed. Recent work has shown that MECP2 can also activate other genes. The MECP2 gene is located on the long (q) arm of the X chromosome in band 28 ("Xq28"), from base pai

protein-coding gene in the species Homo sapiens

InterPro Domain

protein-coding gene in the species Homo sapiens

group of protein complexes

protein-coding gene in the species Homo sapiens

family of protein complexes

protein-coding gene in the species Homo sapiens

family of protein complexes

protein-coding gene in the species Homo sapiens