POLH

Also known as RAD30, RAD30A, XP-V, XPV, DNA polymerase eta, polymerase (DNA) eta

protein-coding gene in the species Homo sapiens

In the Vinony graph

Within Vinony's link graph, POLH is referenced by 413 other articles, and connects out to PubMed, Ensembl genome database project and protein.

It sits within the topics DNA-binding proteins, DNA replication and Genes on human chromosome 6.

Its subject is documented across 7 Wikipedia language editions.

Gene data

POLH

Name: DNA polymerase eta
Type: protein-coding
Position: 43,575,537–43,628,361 (+)
Aliases: RAD30, RAD30A, XP-V, XPV
Ensembl: ENSG00000170734
RefSeq RNA: NM_001291969.2, NM_001291970.2, NM_006502.3, XM_047418900.1, XM_054355671.1
RefSeq protein: NP_001278898.1, NP_001278899.1, NP_006493.1, XP_047274856.1, XP_054211646.1

This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].