4-Br-3,5-DMA

4-Br-3,5-DMA, also known as 4-bromo-3,5-dimethoxyamphetamine or as 4-bromo-TMA, is a psychoactive drug of the phenethylamine, amphetamine, and 3C families related to mescaline. It is the analogue of TMA in which the methoxy group at the 4 position has been replaced with a bromine atom. In addition, 4-Br-3,5-DMA is a positional isomer of DOB with the methoxy group at the 2 position located instead at the 3 position.

==Use and effects== In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 4-Br-3,5-DMA's dose range as 4 to 10mg orally and its duration as 8 to 12hours. In earlier publications, the dose range was listed as 3 to 6mg orally and was described as producing threshold effects. The effects of 4-Br-3,5-DMA have been reported to include very shallow threshold effects to a "plus-two" on the Shulgin Rating Scale depending on dose, very little if any sensory distortion, pronounced analgesia or tactile anesthesia and numbing of the skin and extremities, and teeth rubbiness. Although it produces both mental and physical effects, there were no clear hallucinogenic or visual effects at tested doses. Shulgin said that it is a "remarkably effective anesthetic to skin surfaces" taken systemically at his listed doses and suggested that it might be a "narcotic" rather than a psychedelic.