Structure via PubChem · Public domain (PubChem)
levonordefrin
Sign in to saveAlso known as α-Me-NE, α-methylnorepinephrine, alpha-methylnoradrenaline, Neo-cobefrin, (-)-cobefrin, alpha-Methylnoradrenaline, Corbadrine, L-alpha-methylnoradrenaline
Corbadrine, sold under the brand name Neo-Cobefrine and also known as levonordefrin and α-methylnorepinephrine, is a catecholamine sympathomimetic used as a topical nasal decongestant and vasoconstrictor in dentistry in the United States. It is usually used in a pre-mixed solution with local anesthetics, such as mepivacaine.
Chemical data
- Formula
- C9H13NO3
- Molecular weight
- 183.2 g/mol
- IUPAC name
- 4-[(1R,2S)-2-amino-1-hydroxypropyl]benzene-1,2-diol
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1960
- Admin. routes
- parenteral
via ChEMBL · EBI
Research
256 papers- Modification of local anesthetic toxicity by vasoconstrictors.Anesthesia progress · 1989
- A prospective, randomized, double-blind comparison of 2% mepivacaine with 1 : 20,000 levonordefrin versus 2% lidocaine with 1 : 100,000 epinephrine for maxillary infiltrations.Anesthesia progress · 2010
- An evaluation of 4% prilocaine with 1:200,000 epinephrine and 2% mepivacaine with 1:20,000 levonordefrin compared with 2% lidocaine with:100,000 epinephrine for inferior alveolar nerve block.Anesthesia progress · 1991
- Anesthetic efficacy and heart rate effects of the supplemental intraosseous injection of 2% mepivacaine with 1:20,000 levonordefrin.Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 1999
- Beta-adrenergic blocking agents and dental vasoconstrictors.Dental clinics of North America · 2010
via PubMed
Wikidata facts
- Mass
- 183.089543
Show 4 more facts
- chemical formula
- C₉H₁₃NO₃
- isomeric SMILES
- C[C@@H]([C@@H](C1=CC(=C(C=C1)O)O)O)N
- canonical SMILES
- CC(C(C1=CC(=C(C=C1)O)O)O)N
- Commons category
- Corbadrine
via Wikidata · CC0
~2 min read
Article
7 sectionsContents
- Pharmacology
- Pharmacokinetics
- Chemistry
- Society and culture
- Names
- References
- External links
Corbadrine, sold under the brand name Neo-Cobefrine and also known as levonordefrin and α-methylnorepinephrine, is a catecholamine sympathomimetic used as a topical nasal decongestant and vasoconstrictor in dentistry in the United States. It is usually used in a pre-mixed solution with local anesthetics, such as mepivacaine.
The drug acts as a non-selective agonist of the α1-, α2-, and β-adrenergic receptors. It is said to have preferential activity at the α2-adrenergic receptor.