Structure via PubChem · Public domain (PubChem)
5-carboxamidotryptamine
Sign in to saveAlso known as 5-CT, 5-Carboxamide tryptamine, 5-Carboxyamidotryptamine
5-Carboxamidotryptamine (5-CT), also known as 5-(aminocarbonyl)tryptamine, is a tryptamine derivative closely related to the neurotransmitter serotonin.
Chemical data
- Formula
- C11H13N3O
- Molecular weight
- 203.24 g/mol
- IUPAC name
- 3-(2-aminoethyl)-1H-indole-5-carboxamide
- SMILES
- C1=CC2=C(C=C1C(=O)N)C(=CN2)CCN
- InChIKey
- WKZLNEWVIAGNAW-UHFFFAOYSA-N
- XLogP
- -0.6
- Polar surface area
- 84.9 Ų
- H-bond donors
- 3
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Mass
- 203.105862
Show 3 more facts
- chemical formula
- C₁₁H₁₃N₃O
- canonical SMILES
- C1=CC2=C(C=C1C(=O)N)C(=CN2)CCN
- subject has role
- serotonin receptor agonists
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
5-Carboxamidotryptamine (5-CT), also known as 5-(aminocarbonyl)tryptamine, is a tryptamine derivative closely related to the neurotransmitter serotonin.
5-CT acts as a non-selective, high-affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 receptors, as well as an agonist of the 5-HT2, 5-HT3, 5-HT6 receptors with lower affinity. It has negligible affinity for the 5-HT1E and 5-HT1F receptors. 5-CT binds most strongly to the 5-HT1A receptor and it was once thought to be selective for this site.
Excerpted from Wikipedia’s “5-carboxamidotryptamine” article, available under the CC BY-SA 4.0 licence.