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5'-nucleotidase
Sign in to saveAlso known as IPR010394, 5-nucleotidase, 5'-ribonucleotide phosphohydrolase, 5'-mononucleotidase
5′-nucleotidase (EC 3.1.3.5) is an enzyme which catalyzes the phosphorylytic cleavage of 5′-nucleotides. Although originally found in snake venom, the activity of 5′-nucleotidase has been described for bacteria and plant cells, and is widely distributed in vertebrate tissue. In mammalian cells the enzyme is predominantly located in the plasma membrane and its primary role is in the conversion of extracellular nucleotides (e.g. 5′-AMP), which are generally impermeable, to the corresponding nucleoside (e.g. adenosine) which can readily enter most cells. Consequently, the enzyme plays a key role
In the Vinony graph
Vinony's link graph records 15 inbound references to 5'-nucleotidase, and connects out to PubMed, PubMed Central and bone.
It is catalogued under the topic EC 3.1.3.
Vinony links it to 5 Wikipedia language editions.
Research
7,618 papers- [5'-nucleotidase].Nihon rinsho. Japanese journal of clinical medicine · 2003
- The elegant complexity of mammalian ecto-5'-nucleotidase (CD73).Trends in cell biology · 2021
- Pyrimidine 5' nucleotidase deficiency.British journal of haematology · 2003
- IMP-GMP 5'-nucleotidase.Comparative biochemistry and physiology. B, Comparative biochemistry · 1993
- 5'-Nucleotidase: molecular structure and functional aspects.The Biochemical journal · 1992
via PubMed
Wikidata facts
Show 2 more facts
- EC enzyme number
- 3.1.3.5
- Commons category
- 5'-nucleotidase
Sources (3)
via Wikidata · CC0
~6 min read
Encyclopedic overview
11 sectionsContents
- Nomenclature
- Structure
- Active site
- Membrane-bound and soluble forms
- Medical relevance
- 5′ nucleotidase blood test
- Lymphocyte 5′-nucleotidase in immunological disorders
- Relation to lead poisoning
- Cytosolic 5-nucleotidase II superactivity
- References
- External links
5′-nucleotidase (EC 3.1.3.5) is an enzyme which catalyzes the phosphorylytic cleavage of 5′-nucleotides. Although originally found in snake venom, the activity of 5′-nucleotidase has been described for bacteria and plant cells, and is widely distributed in vertebrate tissue. In mammalian cells the enzyme is predominantly located in the plasma membrane and its primary role is in the conversion of extracellular nucleotides (e.g. 5′-AMP), which are generally impermeable, to the corresponding nucleoside (e.g. adenosine) which can readily enter most cells. Consequently, the enzyme plays a key role in the metabolism of nucleotides.
The enzyme has a wide substrate specificity for nucleotides and has been shown to hydrolyze 5′-nucleotides rapidly, ribose-5-phosphate slowly, and other phosphate esters extremely slowly (if at all).
Excerpted from Wikipedia’s “5'-nucleotidase” article, available under the CC BY-SA 4.0 licence.