7-aminoactinomycin D

Chemical data

Formula

C62H87N13O16

Molecular weight

1270.4 g/mol

IUPAC name

2,7-diamino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide

SMILES

C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=CC(=C(C4=C3N=C5C(=C(C(=O)C(=C5O4)C)N)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)C)N

InChIKey

YXHLJMWYDTXDHS-IRFLANFNSA-N

XLogP

3.1

Polar surface area

382 Ų

H-bond donors

6

H-bond acceptors

19

Formal charge

0

via PubChem

Drug data · ChEMBL

Molecule type

Small molecule

via ChEMBL · EBI

• Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis.Acta pharmaceutica Sinica. B · 2020
• 7-Aminoactinomycin D for apoptosis staining in flow cytometry.Analytical biochemistry · 2012
• Multiparametric flow cytometric analysis of biochemical and functional events associated with apoptosis and oncosis using the 7-aminoactinomycin D assay.Journal of immunological methods · 2002
• Location of 7-Aminoactinomycin D in Micellar Medium Depends on Ionic Nature of the Surfactant Head Group.Luminescence : the journal of biological and chemical luminescence · 2025
• Actinomycin D and 7-aminoactinomycin D binding to single-stranded DNA.Biochemistry · 1991

via PubMed

Wikidata facts

Subclass of

chemical compound

Mass

1269.639

via Wikidata · CC0