File:Adenine_numbered.svg · Wikimedia Commons · See Wikimedia Commons
adenine
Sign in to saveAlso known as Adenin, Ade, 7H-purin-6-amine, 3,6-Dihydro-6-iminopurine, 6-Amino-1H-purine, 6-Amino-Purine, 9H-Purin-6-ylamine, Vitamin B4
Adenine (symbol A, or Ade) is a purine nucleotide base that is found in DNA, RNA, and ATP. Usually a white crystalline subtance. The shape of adenine is complementary and pairs to either thymine in DNA or uracil in RNA. In cells adenine, as an independent molecule, is rare. It is almost always covalently bound to become a part of a larger biomolecule.
OverviewAI-generated
Adenine is a chemical compound with the formula C₅H₅N₅. Its IUPAC name is 7H-purin-6-amine. The substance has a mass of 135.054 and a density of 1.6. It exhibits a melting point of 360.
Chemical properties include a charge of 0, two hydrogen bond donors, and four hydrogen bond acceptors. The calculated xlogp value is -0.1, and the topological polar surface area is 80.5.
The compound is associated with 97964 entries in PubMed literature. It is also referenced by 802 other encyclopedia articles.
Synthesized by Vinony from 20 facts across 4 sources: Wikidata, PubChem, PubMed, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Chemical data
- Formula
- C5H5N5
- Molecular weight
- 135.13 g/mol
- IUPAC name
- 7H-purin-6-amine
- SMILES
- C1=NC2=NC=NC(=C2N1)N
- InChIKey
- GFFGJBXGBJISGV-UHFFFAOYSA-N
- XLogP
- -0.1
- Polar surface area
- 80.5 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
97,964 papers- On the evolution of protein-adenine binding.Proceedings of the National Academy of Sciences of the United States of America · 2020Narunsky A, Kessel A, Solan R et al.DOI: 10.1073/pnas.1911349117
- Novel derivatives of brincidofovir and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine inhibit orthopoxviruses and human adenoviruses more potently than brincidofovir.Signal transduction and targeted therapy · 2025Zhang Y, Wan Y, Guo C et al.DOI: 10.1038/s41392-025-02207-w
- [Adenine phosphoribosyltransferase (APRT)].ReviewNihon rinsho. Japanese journal of clinical medicine · 2003Taniguchi A
- A new method for sequencing DNA.Proceedings of the National Academy of Sciences of the United States of America · 1977Maxam AM, Gilbert WDOI: 10.1073/pnas.74.2.560
- Adenine suppresses inflammatory response in vascular smooth muscle cells via modulating AMPK/p53/NF-κB cascade.European journal of pharmacology · 2025Lin CM, Peng YH, Chen HM et al.DOI: 10.1016/j.ejphar.2025.178239
- Adenine N6-methylation in diverse fungi.Nature genetics · 2017Seidl MFDOI: 10.1038/ng.3873
- Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors.Nature biomedical engineering · 2022Davis JR, Wang X, Witte IP et al.DOI: 10.1038/s41551-022-00911-4
- [Adenine phosphoribosyltransferase (APRT) deficiency].ReviewRyoikibetsu shokogun shirizu · 1998Taniguchi A
via PubMed
Wikidata facts
- Has part
- carbon
- Mass
- 135.054
- Has use
- medication
Show 7 more facts
- Commons category
- Adenine
- found in taxon
- Saccharomyces cerevisiae
- chemical formula
- C₅H₅N₅
- canonical SMILES
- C1=NC2=C(N1)C(=NC=N2)N
- melting point
- 360
- density
- 1.6
- subject has role
- primary metabolite
Sources (6)
via Wikidata · CC0
~5 min read
Encyclopedic overview
7 sectionsContents
- Structure
- Biosynthesis
- Function
- History
- Notes
- References
- External links
Adenine (symbol A, or Ade) is a purine nucleotide base that is found in DNA, RNA, and ATP. Usually a white crystalline subtance. The shape of adenine is complementary and pairs to either thymine in DNA or uracil in RNA. In cells adenine, as an independent molecule, is rare. It is almost always covalently bound to become a part of a larger biomolecule.
Adenine has a central role in cellular respiration. It is part of adenosine triphosphate which provides the energy that drives and supports most activities in living cells, such as protein synthesis, chemical synthesis, muscle contraction, and nerve impulse propagation. In respiration it also participates as part of the cofactors nicotinamide adenine dinucleotide, flavin adenine dinucleotide, and Coenzyme A.
Excerpted from Wikipedia’s “adenine” article, available under the CC BY-SA 4.0 licence.
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