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GeneQ18035083· pop 5· linked from 492 articles

LPAR6

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Also known as ARWH1, HYPT8, LAH3, P2RY5, P2Y5, lysophosphatidic acid receptor 6, LPA-6

Lysophosphatidic acid receptor 6, also known as LPA6, P2RY5 and GPR87, is a protein that in humans is encoded by the LPAR6 gene. LPA6 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Gene data

LPAR6
Name
lysophosphatidic acid receptor 6
Type
protein-coding
Position
48,327,364–48,444,704 (−)
Aliases
ARWH1, HYPT8, LAH3, LPA-6, P2RY5, P2Y5
Ensembl
ENSG00000139679
RefSeq RNA
NM_001162497.3, NM_001162498.3, NM_001377316.2, NM_001377317.2, NM_005767.7
RefSeq protein
NP_001155969.1, NP_001155970.1, NP_001364245.1, NP_001364246.1, NP_005758.2

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009].

Gene Ontology

Pathways

Phospholipase D signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Signal TransductionSignaling by GPCRClass A/1 (Rhodopsin-like receptors)GPCR downstream signallingG alpha (q) signalling eventsP2Y receptors

via MyGene.info

Gene · Ensembl

lysophosphatidic acid receptor 6

Symbol
LPAR6
Biotype
Protein coding
Organism
Homo sapiens
Location
13:48,327,364-48,444,704
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~2 min read

Encyclopedic overview

5 sections
Contents
  • Role in hair growth/loss
  • See also
  • References
  • Further reading
  • External links

Lysophosphatidic acid receptor 6, also known as LPA6, P2RY5 and GPR87, is a protein that in humans is encoded by the LPAR6 gene. LPA6 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation.

Excerpted from Wikipedia’s “LPAR6” article, available under the CC BY-SA 4.0 licence.

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