ADRA2A

Name

adrenoceptor alpha 2A

Type

protein-coding

Position

111,077,029–111,080,907 (+)

Aliases

ADRA2, ADRA2R, ADRAR, ALPHA2AAR, FPLD8

Ensembl

ENSG00000150594

RefSeq RNA

NM_000681.4

RefSeq protein

NP_000672.3

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. [provided by RefSeq, Sep 2019].

via MyGene.info

Gene · Ensembl

adrenoceptor alpha 2A

Symbol

ADRA2A

Biotype

Protein coding

Organism

Homo sapiens

Location

10:111,077,029-111,080,907

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Alpha-2A adrenergic receptor 9PLN.png

via Wikidata · CC0