FZD6
Sign in to saveAlso known as FZ-6, FZ6, HFZ6, NDNC10, frizzled class receptor 6, NDNC1
Frizzled-6 (Fz-6) is a protein that in humans is encoded by the FZD6 gene.
In the Vinony graph
Vinony's link graph records 486 inbound references to FZD6, and connects out to PubMed, Ensembl genome database project and protein.
It sits within the topics Genes on human chromosome 8 and G protein-coupled receptors.
Vinony links it to 6 Wikipedia language editions.
Gene data
FZD6- Name
- frizzled class receptor 6
- Type
- protein-coding
- Position
- 103,298,433–103,332,866 (+)
- Aliases
- FZ-6, FZ6, HFZ6, NDNC1, NDNC10
- Ensembl
- ENSG00000164930
- RefSeq RNA
- NM_001164615.2, NM_001164616.2, NM_001317796.2, NM_003506.4, NR_133921.2
- RefSeq protein
- NP_001158087.1, NP_001158088.1, NP_001304725.1, NP_003497.2
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
frizzled class receptor 6
- Symbol
- FZD6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:103,298,433-103,332,866
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 2617
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8323
- genomic end
- 104345094
- genomic start
- 104310661
- chromosome
- human chromosome 8
- cytogenetic location
- 8q22.3
- expressed in
- hair follicle
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Frizzled-6 (Fz-6) is a protein that in humans is encoded by the FZD6 gene.
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif. Fz-6 is believed to be the receptor for the WNT4 ligand.
Excerpted from Wikipedia’s “FZD6” article, available under the CC BY-SA 4.0 licence.