AGAP2
Sign in to saveAlso known as CENTG1, GGAP2, PIKE, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the AGAP2 gene.
Gene data
AGAP2- Name
- ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
- Type
- protein-coding
- Position
- 57,723,761–57,742,157 (−)
- Aliases
- CENTG1, GGAP2, PIKE
- Ensembl
- ENSG00000135439
- RefSeq RNA
- NM_001122772.3, NM_014770.4, XM_005268625.4, XM_005268626.3, XM_054371030.1
- RefSeq protein
- NP_001116244.1, NP_055585.1, XP_005268682.1, XP_005268683.1, XP_054227005.1
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
- Image
- Protein CENTG1 PDB 2bmj.png
Show 5 more facts
- HomoloGene ID
- 86815
- exact match
- identifiers.org/ncbigene/116986
- genomic start
- 58118980
- genomic end
- 58135940
- cytogenetic location
- 12q14.1
Sources (3)
via Wikidata · CC0
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Article
4 sectionsContents
- Interactions
- References
- External links
- Further reading
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the AGAP2 gene.
== Interactions == CENTG1 has been shown to interact with: EPB41L1, HOMER1 and PIK3R1.
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