ALDH3A1

Also known as ALDH3, ALDHIII, aldehyde dehydrogenase 3 family member A1, Aldehyde dehydrogenase 3 family, member A1

protein-coding gene in the species Homo sapiens

Gene data

ALDH3A1

Name: aldehyde dehydrogenase 3 family member A1
Type: protein-coding
Position: 19,737,984–19,748,943 (−)
Aliases: ALDH3, ALDHIII
Ensembl: ENSG00000108602
RefSeq RNA: NM_000691.5, NM_001135167.1, NM_001135168.1, NM_001330150.2, XM_011523731.3
RefSeq protein: NP_000682.3, NP_001128639.1, NP_001128640.1, NP_001317079.1, XP_011522033.1

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008].