ALDH1L1

Also known as 10-FTHFDH, 10-fTHF, FDH, FTHFD, aldehyde dehydrogenase 1 family member L1

10-formyltetrahydrofolate dehydrogenase is an enzyme that in humans is encoded by the ALDH1L1 gene.

Gene data

ALDH1L1

Name: aldehyde dehydrogenase 1 family member L1
Type: protein-coding
Position: 126,103,561–126,197,994 (−)
Aliases: 10-FTHFDH, 10-fTHF, FDH, FTHFD
Ensembl: ENSG00000144908
RefSeq RNA: NM_001270364.2, NM_001270365.2, NM_012190.4, NM_144776.1, NR_072979.2
RefSeq protein: NP_001257293.1, NP_001257294.1, NP_036322.2, XP_006713544.1, XP_011510657.1

The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012].

Pathways

One carbon pool by folate - Homo sapiens (human)Metabolism Metabolism of folate and pterines Metabolism of water-soluble vitamins and cofactors Metabolism of vitamins and cofactors Folate-Alcohol and Cancer Pathway Hypotheses One-carbon metabolism

via MyGene.info

Gene · Ensembl

aldehyde dehydrogenase 1 family member L1

Symbol: ALDH1L1
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:126,103,561-126,197,994
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein ALDH1L1 PDB 1s3i.png

Show 8 more facts

HomoloGene ID: 122031
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/10840
genomic end: 125916837
genomic start: 125822412
chromosome: human chromosome 3
cytogenetic location: 3q21.3
expressed in: caudate nucleus

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Encyclopedic overview

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References
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Further reading

10-formyltetrahydrofolate dehydrogenase is an enzyme that in humans is encoded by the ALDH1L1 gene.

The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning.

Excerpted from Wikipedia’s “ALDH1L1” article, available under the CC BY-SA 4.0 licence.