ALDH3B2

Also known as ALDH8, aldehyde dehydrogenase 3 family member B2

Aldehyde dehydrogenase family 3 member B2 is an enzyme that, in humans, is encoded by the ALDH3B2 gene.

Gene data

ALDH3B2

Name: aldehyde dehydrogenase 3 family member B2
Type: protein-coding
Position: 67,662,155–67,681,224 (−)
Aliases: ALDH8
Ensembl: ENSG00000132746
RefSeq RNA: NM_000695.3, NM_001031615.3, NM_001354345.3, NM_001393400.1, NM_001393401.1
RefSeq protein: NP_001026786.3, NP_001341274.2, NP_001380329.1, NP_001380330.1, NP_001380331.1

This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. Altered methylation patterns at this locus have been observed in spermatozoa derived from patients exhibiting reduced fecundity. [provided by RefSeq, Aug 2017].

Gene Ontology

Biological process

alcohol metabolic process ethanol catabolic process aldehyde metabolic process aldehyde metabolic process lipid metabolic process sphingolipid catabolic process

Molecular function

3-chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase (NAD+) activity aldehyde dehydrogenase (NAD+) activity aldehyde dehydrogenase [NAD(P)+] activity protein binding oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor long-chain fatty aldehyde dehydrogenase (NAD+) activity

Cellular component

cytoplasm lipid droplet lipid droplet plasma membrane

Pathways

Glycolysis / Gluconeogenesis - Homo sapiens (human)Histidine metabolism - Homo sapiens (human)Tyrosine metabolism - Homo sapiens (human)Phenylalanine metabolism - Homo sapiens (human)beta-Alanine metabolism - Homo sapiens (human)Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)Drug metabolism - cytochrome P450 - Homo sapiens (human)Chemical carcinogenesis - Homo sapiens (human)Metabolism Sphingolipid metabolism

via MyGene.info

Gene · Ensembl

aldehyde dehydrogenase 3 family member B2

Symbol: ALDH3B2
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:67,662,155-67,681,224
Strand: Reverse (−)
Assembly: GRCh38

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Encyclopedic overview

3 sections

Contents

References
External links
Further reading

Aldehyde dehydrogenase family 3 member B2 is an enzyme that, in humans, is encoded by the ALDH3B2 gene.

This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene for this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized.

Excerpted from Wikipedia’s “ALDH3B2” article, available under the CC BY-SA 4.0 licence.